1686557
India
1
apa-no-doi-no-issue
50
date
desc
title
4099
https://klasienhorstman.nl/phekroom/zotpress/
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Lall, D., Engel, N., Devadasan, N., Horstman, K., & Criel, B. (2020). Team-based primary health care for non-communicable diseases: complexities in South India. Health Policy and Planning, 35, ii22–ii34.
Lall, D., Engel, N., Srinivasan, P. N., Devadasan, N., Horstman, K., & Criel, B. (2020). Improving primary care for diabetes and hypertension: findings from implementation research in rural South India. BMJ Open, 10, e040271.
Lall, D., Engel, N., Devadasan, N., Horstman, K., & Criel, B. (2019). Challenges in primary care for diabetes and hypertension: an observational study of the Kolar district in rural India. BMC Health Services Research, 19, 44.
Lall, D., Engel, N., Devadasan, N., Horstman, K., & Criel, B. (2018). Models of care for chronic conditions in low/middle-income countries: a 'best fit' framework synthesis. BMJ Global Health, 3, e001077.
